Cellular Phone (Total 237373 Papers Found)

  • Stan Schein, R. Desimone,
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1990
Spectral properties of 129 cells in the V4 area of 5 macaque monkeys were studied quantitatively with narrow-band and broad-band colored lights. The large majority of cells exhibited some degree of wavelength sensitivity within their receptive fields. The half-bandwidth of the primary peak in the spectral-response curve was less than 50 nm for 72% of the cells; the mean half-bandwidth of these cells, 27 nm, is similar to that found for color-opponent ganglion cells and cells in the parvocellular ...
After performing the miracles that takes us from conception to birth, and then to sexual maturation and adulthood, natural selection was unable to favor the development of a more elementary mechanism that would simply maintain those earlier miracles forever. The manifestations of this failure are called aging. Because few feral animals age, evolution could not have favored a genetic program for age changes. Natural selection favors animals that are most likely to become reproductively successful ...
That NK cell receptors engage fast-evolving MHC class I ligands suggests that they, too, evolve rapidly. To test this hypothesis, the structure and class I specificity of chimpanzee KIR and CD94:NKG2 receptors were determined and compared to their human counterparts. The KIR families are divergent, with only three KIR conserved between chimpanzees and humans. By contrast, CD94:NKG2 receptors are conserved. Whereas receptors for polymorphic class I are divergent, those for nonpolymorphic class I ...
In Vero monkey cells and HEp-2 human epidermoid carcinoma cells infected with herpes simplex virus 1 the proteins beta-COP, galactosyltransferase, and alpha-mannosidase II associated with the Golgi apparatus appear to be associated with numerous smaller structures dispersed throughout the cytoplasm. Concomitantly, the intracytoplasmic ligands of lectins normally associated wholly (Helix pomatia or Ricinus communis agglutinin) or in part (wheat germ agglutinin) with the Golgi apparatus increased ...
PURPOSE Aggressive T-cell lymphomas (ATCLs) represent 10% to 15% of non-Hodgkin's lymphomas (NHLs) in adults. ATCLs show a worse prognosis than B-cell lymphomas. PATIENTS AND METHODS On behalf of the Société Française de Greffe de Moëlle et de Thérapie Cellulaire, we conducted a retrospective analysis including 77 ATCL patients who underwent allogeneic stem-cell transplantation (alloSCT). RESULTS The different diagnosis included anaplastic large-cell lymphoma (ALCL; n = 27), peripheral ...
The paper presents an approach that reduces several difficulties related to the determination of induced transmembrane voltage (ITV) on irregularly shaped cells. We first describe a method for constructing realistic models of irregularly shaped cells based on microscopic imaging. This provides a possibility to determine the ITV on the same cells on which an experiment is carried out, and can be of considerable importance in understanding and interpretation of the data. We also show how the finit ...
The present study examines the spatial distribution within rat locus coeruleus of neurons projecting to particular brain regions. In order to accurately recreate, in digital and pictorial formats, the spatial distribution of neurons for the entire nucleus locus coeruleus, three-dimensional reconstructions were created which specified the location of each individual Nissl-stained locus coeruleus cell in each of five nuclei. Dynamic computerized displays were visually analyzed and statistically co ...
Hepatic insulin resistance is an important underlying cause of the metabolic syndrome that manifests itself in diseases such as diabetes type II, atherosclerosis or non-alcoholic fatty liver disease (NAFLD). In this paper, we summarize comprehensively the current state of knowledge pertaining to the molecular mechanisms that lead to insulin resistance in hepatocytes and sinusoidal liver cells. In hepatocytes, the insulin resistant state is brought about by at least one, but more likely by a comb ...
The hippocampus is thought to have a critical role in episodic memory by incorporating the sensory input of an experience onto a spatial framework embodied by place cells. Although the formation and stability of place fields requires exploration, the interaction between discrete exploratory behaviors and the specific, immediate and persistent modifications of neural representations required by episodic memory has not been established. We recorded place cells in rats and found that increased neur ...
Human immune function undergoes adverse changes with aging, including development of a relative immune deficiency and an immune dysregulated state. The T cells show the largest age-related differences in distribution and function. The antibody production capacity of B cells also shows an age-related decline. Acute bouts of exercise modulate many immune parameters as seen in peripheral blood. With regard to NK cell activity, a single bout of moderate exercise seems to be well tolerated by the eld ...
Airway epithelial cells in culture respond to extracellular adenosine 5'-triphosphate (ATP) by increasing their intracellular Ca2+ concentration ([Ca2+]i). The effective concentration of ATP that elicited a Ca2+ response equal to 50% of the maximal response (EC50) was 0.5 microM. Release of ATP from a pipette to form a local gradient of ATP increased [Ca2+]i of individual cells in a sequential manner. Cells closest to the pipette showed an immediate increase in [Ca2+]i while more distal cells di ...
Physical activity is associated with reduced risk of several cancers, including aggressive prostate cancer. The mechanisms mediating the effects are not yet understood; among the candidates are modifications of endogenous hormone levels. Long-term exercise is known to reduce serum levels of growth stimulating hormones. In contrast, the endocrine effects of acute endurance exercise include increased levels of mitogenic factors such as GH and IGF-1. It can be speculated that the elevation of serum ...
THE geographical distribution of erythrocyte glucose-6-phosphate dehydrogenase deficiency is now-known to be widespread. Thus, this genetically determined enzyme defect has been shown to be present in parts of Africa, Asia and Europe, and in some Indian groups in South America1. Marked variations in the incidence of the defect have been observed between different populations and in some instances between different groups in the same population. In south-east Asia recent work has shown the trait ...
Inflammation involves in many cigarette smoke (CS) related diseases including the chronic obstructive pulmonary disease (COPD). Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation. CS and cigarette smoke extracts (CSE) both induce IL-8 secretion and subsequently, IL-8 recruits inflammatory cells into the lung parenchyma. However, the molecular and cellular mechanisms by which CSE triggers IL-8 release remain not completely understood. In this study, we identif ...
Our previous results revealed that FAM172A was significantly downregulated in liver tissue from hepatocellular carcinoma or cirrhotic patients. The present study was designed to elucidate the regulatory role of FAM172A in HepG2 cells. In order to determine the expression of the FAM172A protein, western blot analysis was performed. Confocal laser scanning technique was used to observe the localization of FAM172A in HepG2 cells. Surface p ...
The heart is a muscle. Muscles are made up of myocytes. These may differ in form and function, but—in essence—they are the cells in which we are interested when we consider the structural makeup of the heart. Likewise, when we assess electrical coupling of cardiac cells by connexins, we are often content to assume that gap junctions occur exclusively—or at least in the overwhelming majority of cases—between homologous cell types. It is sobering, in this context, to reflect on the fact th ...
One of the most enduring mysteries in biology concerns how tissue growth and pattern are controlled during development. During fly development, many body segments contain disc-shaped pouches of cells known as imaginal discs, each containing the primordium of a specific adult limb (e.g., a wing or leg). The discs arise as small handfuls of embryonic cells, but soon thereafter undergo an explosion of growth and patterning governed by morphogens, signaling molecules that are secreted by special org ...
In the brain, glia represents the cell population that expresses the highest level of connexins, the membrane protein constituents of gap junction channels and hemichannels. This statement has initially led to propose the existence of a glial syncytium. Since then, functional studies have established that connexin channel-mediated communication between glial cells was more restricted and plastic that primarily thought. In particular, this is the case for astrocytes that form functional networks ...
Cells in an early embryo need to downsize their DNA. Ladouceur et al. show that a cell’s size and the size of its nucleus determine how small its chromosomes become (1). Like someone who’s moved from a house to an apartment, cells in an early embryo run into space limitations. The embryo remains the same size for its fi rst few divisions, so the cells have to become much smaller, shrinking by as much as 99%. Some components, such as individual mitochondria and clathrin-coated vesicles, seemi ...
Epidemiological and experimental studies have suggested that Hepatitis C virus (HCV) infection is associated with the development of type 2 diabetes. Pancreatic beta cell failure is central to the progression of type 2 diabetes. Using virus infection system, we investigate the influence of HCV infection on the fate of the insulinoma cell line, MIN6. Our experiments demonstrate that the HCV virion itself is indispensable and has a dose- and time-dependent cytopathic effect on the cells. HCV infec ...
This article is the authors' opinion of the roles of the signal transducer Mps one binder 2 (MOB2) in the control of cell cycle progression and the DNA Damage Response (DDR). We recently found that endogenous MOB2 is required to prevent the accumulation of endogenous DNA damage in order to prevent the undesired, and possibly detrimental, activation of cell cycle checkpoints. In this regard, it is noteworthy that MOB2 has been linked biochemically to the regulation of the NDR1/2 (aka STK38/STK38L ...
A granular cell tumor (GCT) in a 39-year-old white man is reported. It was localized in the intrapancreatic part of the common bile duct and caused obstruction of the bile downflow. The patient underwent radical surgical procedures because a malignant tumor was clinically suspected. Macroscopically, the tumor appeared as a duct stricture caused by diffuse infiltration of neoplastic cells in the walls. In the cytoplasm smaller and larger PAS-positive granules were present and constantly reactive ...
In order to understand the mechanisms of tumor promotion, the relationship between the early effects induced by promoters and the enhancement of transformation was investigated using transformable, promoter-sensitive mouse clone Balb/3T3 A31-1-1. Emphasis was placed on the measurement of all parameters in the same clonal line under the same conditions. The potentials of various derivatives of phorbol ester, indole alkaloid, and polyacetate for enhancing transformation in 3-methylcholanthrene-ini ...
Chronic natural killer cell lymphocytosis (CNKL) is characterized by greatly increased numbers of natural killer (NK) cells and patients with this disease may survive for long periods. This is in contrast to patients with leukemic proliferations of NK cells who can have a rapidly progressive clinical course. We identified a pediatric patient who was largely healthy who had CNKL and we sought to determine if the expanded CD16(+)CD3(-) population in this patient functions differently than classica ...
OBJECTIVE Depression is common in people living with HIV/AIDS and there is some evidence that depressive symptoms may have adverse effects on immune functioning. The purpose of this study was to determine the prevalence of current depressive disorder in patients with HIV/AIDS and its association with CD4 cell count. METHODS A consecutive sample of 310 patients with HIV/AIDS attending Out-patient clinic in Ahmadu Bello University Teaching Hospital (A.B.U.T.H.), Zaria, Nigeria was assessed. The ...
Serial frontal and sagittal sections through the organum vasculosum laminae terminalis (OVLT) of the male Mongolian gerbil (Meriones unguiculatus) were incubated with an antibody against substance P and stained by the indirect peroxidase anti-peroxidase technique. A high density of nerve fibres with large-sized terminals exhibiting substance P-immunoreactivity was observed in the OVLT in close relation to the blood vessels both in the internal and the external zone of the organ. In addition, a f ...
The term "gliosis" is very commonly used in neuropathological parlance, and is applied most often to indicate an increase of glia cells in degenerating white or gray matter. The mechanism by which this increase develops is not known, and two theories exist to explain it. According to the first, there is an actual increase of cells due to their multiplication; according to the second, the increase is only apparent, being caused by the shrinkage of the tissue. Lassek and Shapiro (1) compared the n ...
Use of information and communication technology is becoming popular with time as this technology is coming with a lot of lavishness so people are demanding more of it. Electronic items have taken a status symbol in our lives. In India rich class is using up to date devices like cell phones, laptops, computers, microwave ovens, fridge, televisions etc and then pass it on to the poor class. There is no proper way for disposal or recycling of these items. This paper discuses about the increasing pr ...
In order to elucidate active oxygen in liver diseases, activities, electrophoretic profiles and immunolocalization of superoxide dismutase (SOD) in human liver specimens were investigated. Activities and electrophoresis were studied using liver homogenates in 41 cases and immunolocalization of Cu, Zn SOD was observed in 87 cases. Total SOD activity in acute viral hepatitis (AVH) and fatty liver (FL) groups was significantly lower than that in non-specific reactive hepatitis (NSRH) group. Cu, Zn ...
1Shiraz Neurosciences Research Center, Shiraz University of Medicine Sciences 2Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran 3NanoTechnology Research Institute, University of Shiraz, Shiraz, Iran 4Shiraz Neurosciences Research Center, Neurosurgery Department, Shiraz University of Medical Sciences, Shiraz, Iran 5Collage of Medicine, Physiology Center, Shiraz, Iran ...
This paper presents a refined centrifugo-magnetophoretic platform enabling 2-dimensional separation of cancer cells from background cells [1]. The multi-force, stopped-flow separation combines centrifugal sedimentation with lateral magnetic deflection. In this way, hydrodynamic stresses and variations typical in pressure-driven microfluidic platforms [2][3] are minimized, and collisions between cells and chamber walls, a common disadvantage of stand-alone magnetic separation systems, is avoided. ...
In short-term primary monolayer cultures of rat hepatocytes, aflatoxin B1 (AFB1) causes a characteristic prelethal cytomorphological response in which peripheral attached cytoplasm contracts segmentally to form finger-like blebs. This response precedes lethal injury as detected by release of lactate dehydrogenase (LDH) into culture medium. We compared the influences of various modifiers of cellular glutathione (GSH) status on cytocidal responses of Fischer 344 rats hepatocytes exposed to AFB1 or ...
Smart phones have pervaded almost all the environments where people perform their day-to-day activities. They are now equipped with embedded sensors, camera, touchscreen, more memory and processing capabilities as well as efficient power saving mechanisms. Together, these improvements enable the mobile devices to perform tasks that are normally run in personal computers like the provisioning of services to other devices. The idea of Mobile Host is not new and this paper tries to extend the resea ...
Radiation therapy using external beam radiation therapy (EBRT) is playing an important role for effective treatment of all kinds of tumors. Peripheral dose is the result of leakage and scatter from multileaf collimators devices (MLCs), counts for 2-10% of the maximum dose given to the patient, depending on the machine used and type of treatment. The present review reveals that despite of the recent advancements in linear accelerators (LINAC) and MLC design and technology, the remaining small amo ...
T he incidence and prevalence of type 2 diabetes (T2D) in youth are steadily increasing. The Centers for Disease Control and Prevention recently published the projected prevalence of T2D in youth using the SEARCH for Diabetes in Youth Study database from 2001 for prevalence and 2002 for incidence. Based on these data and assuming a 2.3% increase annually, it is predicted that the prevalence of T2D in youth could quadruple in 40 years. As in adults with T2D, adolescents develop macrovascular and ...
Warren Mitofsky and Joseph Waksberg were two of the most influential researchers in telephone surveys and survey research methods. Their development of the Mitofsky–Waksberg method for random digit dialing sampling revolutionized telephone sampling and surveys. Jointly and separately, Waksberg and Mitofsky were instrumental in the development of many innovative methods and applications. This article reviews some of their contributions and discusses how their approaches to these problems may be ...
  • Jian Zhang, Yuming Zhao,
  • Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • 2007
A kind of research on mesenchymal stem cells (MSCs) segmentation is reported in this paper. The research of its kind has become more and more popular recently. Top-bottom hat algorithm of gray morphology is applied to image preprocessing. The radius of the ball of the structure function is 30 in the algorithm. After preprocessing, binary image is gained cursoryily through distinguishing foreground from background using two thresholds. Noise is removed by applying morphology algorithm. It is easy ...
Using co-culture technique and 3H-thymidine radioautography we have studied effects of human aortic endothelial cells (EC), isolated separately from zones of low (LP) and high (HP) probability of atherosclerosis of grossly normal and atherosclerotic aortas, on 3H-thymidine incorporation by human intimal smooth muscle cells (SMCs). It was found that EC activity depended on a zone of probability, from which the cells were isolated, and on the degree of atherosclerotic lesion. The first-passage ECs ...
Understanding how individuals with mental illness who receive services at peer support agencies use technology can inform the development of online and mobile health interventions tailored for users in these non-traditional mental health settings. The purpose of this study was to assess the use of technology among individuals with mental illness at peer support agencies. A survey delivered within peer support agencies (PSAs) in one state assessed technology use among individuals ages 18 and over ...
The European Medicines Agency has recommended that alipogene tiparvovec (marketed as Glybera) be authorised for sale in the European Union. Intended to treat lipoprotein lipase deficiency in patients with severe pancreatitis, it is the first gene therapy in Europe to be recommended for this status and is yet to be approved in the United States. The deficiency is a genetic disorder thought to affect no more than one or two people in a million. The new treatment relies on an adeno-associated virus ...
Primary cultures of confluent endothelial cells derived from human umbilical veins produce platelet-activating factor (PAF) (l -alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with appropriate agonists. Highly purified human thrombin and calcium ionophore A23187 stimulate the incorporation of [3H] acetate into a lipid product that has been identified as PAF by its behavior in thin-layer chromatographic and high-performance liquid chromatographic systems, the presence of characteristi ...
OVERVIEW: The needs of automobile drivers are moving in the direction of information in addition to safety and advanced control. With the shift toward information functionality, content services such as searching for information on the Internet, music and picture broadcasting, settlement of charges, traffic information, and emergency call service can be enjoyed while driving an automobile. This is all accomplished with cell phones, wireless LANs (local area networks), road to vehicle communicati ...
A 38-year-old businessman presented with an intensely itching eczematous patch on the anterolateral aspect of each thigh; the lesions, symmetrically localized, were different in size and severity (Fig. 1). He reported a 1-year history of spontaneous variability, with worsening of a lesion matched by improvement on the contralateral side and vice versa. Response to oral antihistamines and topic and/or systemic corticosteroids was temporary. Patch tests were performed with the SIDAPA (Italian Soci ...
Recent research has shown that only the inner hair cells pass information on to the brain while the outer hair cells serve as an active amplifier and thus stimulate the inner cells. The electromotility of the outer hair cells is very vulnerable. If it is lacking, sensorineuronal hearing loss occurs. Substances, that compete for the chloride combining site of the motor protein prestin, such as salicylate, might have a blocking effect on the regulation of electromotility. On the other hand, the co ...
Fibrillation-like beating of cardiac muscle cells in culture was induced by altering the concentrations of various ions. Fine structural changes of cell membrane and intercellular alteration of cardiac muscle cells appeared to be more prominent in cells with fibrilliation-like beating than in others. From the results of the present study, it may be concluded that fibrillation-like beating may occur in the presence of altered concentrations of certain ions, accompanied by fine structural changes ...
The authors present an analysis of the fault tolerant properties and the effects of temperature on an exclusive OR (XOR) gate and a full adder device implemented using quantum-dot cellular automata (QCA) structures. A Hubbard-type Hamiltonian and the Inter-cellular Hartree approximation have been used for modeling, and a uniform random distribution has been implemented for the simulated dot displacements within cells. We have shown characteristic features of all four possible input configuration ...
The quest for novel therapeutic targets in acute myeloid leukemia (AML) is still ongoing. One of such targets, cyclin A1, was shown to be overexpressed in AML including AML stem cells. However, the function of cyclin A1 in AML is largely unknown, and the data on its impact on patients' survival remain controversial. Therefore, we developed a transgenic mouse model of stem cell-directed inducible cyclin A1 overexpression and crossed these mice with PML-RARα-knockin mice, which develop an AML M3- ...
Four cases of prepubertal cryptorchid testes with atypical germ cells were studied. These cells were characteristically large, showing a wide, pale cytoplasm and a large nucleus with both fine and coarse granular chromatin. Ferritin was shown to be absent. It is possible that these cells are dysplastic in nature and that they could form the basis of a premalignant intratubular lesion. Thus periodic follow-up of these patients is recommended. ...
OBJECTIVE To study the effect of glutamate on the expression of vascular endothelial growth factor (VEGF) mRNA and protein in cultured rat astrocytes under hypoxia. METHODS Cultured rat astrocytes were randomly divided control group, glutamate group, hypoxia group and hypoxia+glutamate group. The cells in the control and glutamate groups were cultured under nomoxic condition (95% air and 5% CO(2)), and those in the other two groups under hypoxic condition (94% N(2), 5% CO(2) and 1% O(2)). The ...